From application perspective

decision tree pattern, from top to bottom

their limitations, their uniqueness,

Molecular weight GC-MS/MS

hydrophobic (repel to mix with water, water-fearing), hydrophilic (water-loving)

exclusive compounds with GC-MS/MS: organochlorine pesticides

GC-MS/MS limitations: volatile, thermally stable. Derivatization for hydrophobic compounds with
ESI /API matrix effects with LC-MS/MS, LC-MS/MS: consider isomers,